Pedestrians can access the station via the footbridge from Pipers Row, while National Cycle Route 81 will be maintained along Railway Drive, although cyclists should take care as construction traffic will be operating in the area.
Work on the new car park has increased capacity from 450 to more than 800 long stay parking spaces.
The old entrance to the multi-storey car park has been permanently removed.
The access changes are due to the opening of the city's new railway station building. The new station building benefits from an enhanced ticket office, larger passenger concourse, ample ticket barriers to ease flow onto and off platforms, and much-improved retail and café facilities.
The overall Interchange project will also see a Metro line extension running down Railway Drive to a new stop at the station.
How to access the railway station
Travelling from Stafford Road (A449) direction:
Follow Ring Road St Patricks, onto Ring Road St Davids and take slip road/exit onto Corn Hill.
Travelling from Wednesfield Road (A4124) direction:
Follow Ring Road St Davids (A4150) and take slip road/exit onto Corn Hill.
Travelling from Willenhall Road (A454) direction:
Follow A454 into city centre, straight on at the Horseley Fields lights and right onto Corn Hill.
Travelling from Bilston Island direction:
Take the A454 Middle Cross exit, left at the Horseley Fields (A454) lights and right onto Corn Hill.